SYNVISC® has a strong safety profile. Its high-purity, non-animal derived formulation reduces immunogenic risks and adverse reactions. When administered under sterile conditions by trained professionals, SYNVISC® is well tolerated. Most side effects are mild and transient.

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SYNVISC®

Q: What is SYNVISC®, and How Does It Work?

SYNVISC® is a hyaluronic acid-based viscosupplement used to treat osteoarthritis-related knee pain. It consists of hylan A and B polymers, derived from a highly purified bacterial fermentation process, which closely resemble the natural synovial fluid found in healthy joints. Upon intra-articular injection, SYNVISC® restores the viscoelasticity of synovial fluid, enabling smoother joint movement and effective shock absorption. It reduces mechanical stress on the cartilage and minimizes pain through improved lubrication, enhancing overall joint function without systemic drug intervention.

Q: What Is SYNVISC® Used For?

SYNVISC® is indicated for the treatment of pain in osteoarthritis of the knee in patients who have not responded to conservative, non-pharmacologic therapy and simple analgesics. It is used to: Lubricate and cushion the knee joint Improve mobility in osteoarthritis patients Reduce dependency on oral NSAIDs Delay surgical intervention for joint replacement SYNVISC® supports the joint environment, particularly when endogenous hyaluronic acid levels are depleted.

Q: Why Choose This Brand?

SYNVISC® is one of the most extensively studied viscosupplements on the market, with a long history of global use. Its unique formulation and dual-polymer structure deliver extended joint protection and improved mobility for osteoarthritis patients. Key benefits include: Non-animal origin hyaluronic acid Clinically proven pain relief lasting up to six months Excellent safety profile with minimal side effects Used in over 60 countries with decades of clinical experience Offered in multiple formats for flexible treatment planning Healthcare providers who buy SYNVISC rely on its consistent performance, safety, and global regulatory approvals.

Q: How Long Do Results Last?

Patients typically experience relief within a few weeks of the initial injection, with peak results emerging between 4 to 6 weeks post-treatment. The effects of a SYNVISC® injection may last up to six months , depending on the severity of osteoarthritis and patient activity levels. Repeat treatments can be administered based on clinical evaluation.

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SYNVISC®

Administering Techniques

SYNVISC® is injected directly into the intra-articular space of the knee by a qualified medical professional. The injection technique depends on the patient’s anatomy and the specific product being used.

Joint aspiration may be performed prior to injection
Sterile technique is essential to minimize infection risk
Post-procedure, patients should limit activity for 24–48 hours

Depending on the product format, either a single injection or a 3-injection series is recommended.

SYNVISC® Product Range

SYNVISC® 2 mL Syringe: A three-injection regimen with 16 mg/mL of hylan G-F 20 to be administered at weekly intervals for sustained relief.
SYNVISC ONE® 6 mL Syringe: A single-injection format providing the full treatment dose in one session, offering convenience for both provider and patient.

Each SYNVISC product is prefilled and ready for use under sterile conditions.

Side Effects

SYNVISC® is associated with minimal side effects, which are typically localized and resolve within a few days:

Mild swelling or discomfort at the injection site
Temporary joint stiffness
Occasional warmth or redness in the injected knee

Serious reactions are rare and largely avoidable with proper patient selection and sterile administration.

SYNVISC® vs Competition

Compared to other viscosupplements, SYNVISC® delivers a unique combination of viscosity, cushioning, and extended durability thanks to its proprietary hylan polymer formulation. While products like MONOVISC® and SUPARTZ® are effective, SYNVISC® provides both multi-dose and single-dose formats, offering flexibility for treatment planning.

Clinicians seeking to order SYNVISC ONE online benefit from simplified administration without compromising therapeutic outcome. Whether in single or three-dose formats, SYNVISC® remains a leading viscosupplement trusted by orthopedic professionals worldwide.