Polynucleotides

What are Polynucleotides?

Polynucleotides are DNA fragments used in an injectable form. They do not behave like volume fillers. Instead of changing shape, they work deeper, urging the skin to restore itself. Hydration improves. Elasticity comes back slowly. Texture softens, and the surface feels more balanced.

Patients often notice a glow rather than a sharp change. That is why many clinics recommend them to people who want subtle care. They fit both early prevention and visible repair. Younger patients use them to hold onto resilience. Older patients use them to rebuild what has been lost.

How Do Polynucleotides Work?

The skin is made of cells that build collagen and elastin. With age or stress, these cells slow down. Polynucleotide injections push them back into action. Fibroblasts begin to produce again. Elastic fibers grow stronger.

Hydration is another part. Polynucleotides hold water inside the tissue, giving lasting moisture where creams cannot reach. They also calm oxidative stress. Free radicals that damage skin get neutralized. So the treatment is not only about smoothing lines but about protecting skin from further breakdown.

Polynucleotides Composition

Most polynucleotide products are made from purified salmon DNA. The process removes proteins and leaves only clean DNA chains. This makes them safe and stable for use in humans.

Formulas may differ. Some combine DNA with hyaluronic acid for extra hydration. Others stay pure and focus only on regeneration. Whatever the brand, the goal stays the same: repair from within.

Top Polynucleotides Products

 Kinami Health supplies a focused range of polynucleotides chosen for professional use. Each product has a clear role, giving clinics reliable options for different patient needs.

• NUCLEOFILL™ STRONG: A powerful option for skin that needs deep repair. Often used on mature or severely dehydrated skin where elasticity is low.
• NUCLEOFILL™ MEDIUM PLUS: Designed for patients who need balanced correction. It helps restore hydration while supporting long-term regeneration.
• NUCLEOFILL™ SOFT PLUS: Made for fragile areas, especially around the eyes. Provides gentle repair without adding unnecessary weight.
• NUCLEOFILL™ MEDIUM: A versatile choice for prevention and maintenance. Suitable for younger patients or those beginning aesthetic care.
• CROMA POLYPHIL™ EYE: Specially formulated for the eye area. Improves skin quality where tissue is thinnest and most delicate.

Clinics can buy polynucleotides online through Kinami Health with the assurance that every product is authentic and sourced for professional treatment.

Benefits of Polynucleotides

The main benefit is skin quality. Patients often say their skin feels fresher and stronger. Fine lines fade a little. Dryness eases. Elasticity returns with time. Because the treatment works with the body’s own repair, the results build gradually.

For professionals, flexibility is a strength. They can offer polynucleotide treatments to a wide range of patients. Young, old, preventive, corrective, the treatment adapts. It also fits with other procedures, so clinics do not have to choose one or the other.

Polynucleotides Treatment Areas

The face is the first choice. Cheeks, forehead, and chin all respond well. But the treatment does not stop there. The neck shows creases that can be softened. The chest often looks thin with age, and polynucleotides bring back resilience. Hands, which lose hydration quickly, are another common area.

Even under the eyes, where most fillers are risky, these injections can make a difference. Scarred or stressed skin is another place where clinics use them. This wide reach makes them part of everyday practice, not just a niche tool.

Injection Techniques of Polynucleotides

Technique varies with the area and the patient. Some practitioners go with micro-bolus injections, dropping small amounts across the skin to spread the product evenly. Others prefer a cannula, sliding under the tissue with fewer entry points. For fine lines, serial puncture is still common and gives good control.

There isn’t one method that fits everyone. Skin thickness, age, and comfort all shift the choice. What matters more is that the product lands where it should, without trauma, and with results that look even.

In real practice, techniques blend. A cannula can cover a large area quickly, while a needle finishes the details. Depth changes outcomes, too. Deeper placement brings firmness, while shallow placement keeps hydration closer to the surface.

The product itself also guides technique. Thick formulas can be stubborn through fine needles, so a cannula may handle them better. Lighter solutions pass easily and allow small punctures without issue. Patients add another layer of decision. Some are relaxed through multiple injections, while others prefer fewer passes. The approach bends to the situation, not to a fixed rule.

Polynucleotides vs. Other Dermal Fillers

Fillers give structure. They lift, restore volume, and reshape contours. Polynucleotides do none of that. They fix the skin itself. They rebuild elasticity, restore hydration, and improve surface texture.

Many clinics use both. A filler restores cheeks or jawline. A polynucleotide treatment smooths and strengthens the skin above it. The two are not in conflict. They are partners in modern practice.

Potential Side Effects

Side effects happen with any needlework. Most are short-lived: faint redness, mild swelling, tiny bruises where the needle went in. These are clear without intervention and do not affect outcomes. Discomfort is usually small and settles as the skin calms.

Some people notice a feeling of tightness or warmth for a day. Small bumps can appear when the product sits close to the surface; they tend to flatten as the tissue redistributes fluid. Under-eye and neck areas bruise more easily because the skin is thin, so expect a slower fade there. Makeup is often postponed until the next day, which helps keep the area clean while it settles.

Less common events can occur. Local irritation, itching, or hives point to sensitivity. Infection is rare but possible with any injection. Vascular issues are very uncommon and require immediate attention. Clear pre-treatment screening, sterile handling, and authentic product reduce risk at every step.